PPT Slide

Regression Interval Mapping

To estimate QTL position and effect separately

Yi = m + bQ XQ,i + ei

XQ,i = Prob(Q | marker genotype, QTL position)

E(bQ) = a+d

Backcross

Fit Model for various positions

of QTL (1 cM steps)

Position with lowest RSS or F-test gives

best estimate of r1 and bQ (=a)

Haley and Knott (1992)

Heredity 69: 315